During the Cultural Revolution, the Chinese mainland underwent its first period of significant seismic activity since the founding of New China. In order to limit the damage of the earthquakes, a large-scale earthquake prediction program, characterized by “collective monitoring, collective defense”, was launched across China. However, levels of science and technology were not advanced enough to predict earthquakes. Thus, the main problems were how to carry out the program of earthquake prediction and how to popularize earthquake prediction knowledge among the masses. It was against this background that the journal Dizhen Zhanxian was founded. This article reviews its foundation and publication process, and introduces the major content and features of the journal. On this basis, the article explores the influence of Dizhen Zhanxian in the process of the popularization of earthquake prediction knowledge.